کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8841543 1615024 2018 25 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Inhibition of BDNF production by MPP+ through up-regulation of miR-210-3p contributes to dopaminergic neuron damage in MPTP model
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Inhibition of BDNF production by MPP+ through up-regulation of miR-210-3p contributes to dopaminergic neuron damage in MPTP model
چکیده انگلیسی
The neurotrophin brain-derived neurotrophic factor (BDNF) has been involved in supporting of neuron survival. The observation of reduced level of BDNF in the substantia nigra (SN) of Parkinson's disease (PD) patients suggests its important role in neuron protection in PD pathogenesis. However, the mechanism underlying the down-regulation of BDNF in PD was largely unknown. In this study, we found that miR-210-3p is involved in the regulation of BDNF production by 1-methyl-4-phenylpyridinium (MPP+). MPP+ inhibits the BDNF production in SH-SY5Y cells through a transcription independent manner. Moreover, miR-210-3p, which targets BDNF mRNA, is up-regulated by MPP+ in SH-SY5Y cells. Importantly, inhibition of miR-210-3p prevents the reduction of BDNF production by MPP+ and improves the DA neuron survival in 1-methyl-4-phenyl-1,2,3,6-tetra hydropyridine (MPTP) model. Together, we demonstrated up-regulation of miR-210-3p by MPP+ reduces the BDNF production and contributes to the DA neuron damage.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 675, 14 May 2018, Pages 133-139
نویسندگان
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