کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8841600 1615026 2018 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Inhibitory effect of several sphingolipid metabolites on calcineurin
ترجمه فارسی عنوان
اثر مهاری متابولیت های اسپینگولایپید بر روی کلسینیرین
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی
Neurons have well-developed membrane microdomains called “rafts” that are recovered as a detergent-resistant membrane microdomain fraction (DRM). NAP-22 is one of the major protein components of neuronal DRM. In a previous study, we showed that DRM-derived NAP-22 binds ganglioside and the inhibitory effect of ganglioside to calcineurin (CaN), a neuron-enriched calmodulin-regulated phosphoprotein phosphatase. Considering the important roles of CaN in neurons, identification of other cellular regulators of CaN could be a good clue to understand the molecular background of neuronal function. In this study, we screened the effect of several membrane lipid-derived molecules on the CaN activity and found sphingosine and some sphingosine-derived metabolites such as sphingosylphosphorylcholine, galactosylsphingosine (psychosine), and glucosylsphingosine, have inhibitory effect on CaN through the interaction with calmodulin.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 673, 23 April 2018, Pages 132-135
نویسندگان
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