کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8841669 | 1615028 | 2018 | 24 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The Sonic Hedgehog signaling pathway regulates inferior alveolar nerve regeneration
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کلمات کلیدی
glioma-associated oncogene homologSMOPTCH1GliPGP9.5PBSDILRT-PCRSHH signalingGFPMBPFITCfluoresceinisothiocyanate - fluoresceinosothiocyanateIAN - ایانNerve regeneration - بازسازی عصبPostoperative - بعد از عملnerve transection - ترشح عصبShh - خیرSchwann cell - سلول شوانSmoothened - صافsonic hedgehog - صدای جیر جیرinferior alveolar nerve - عصب آلوئولی زیرینPeripheral nerve - عصب محیطیPhosphate buffered saline - فسفات بافر شورreverse transcription polymerase chain reaction - واکنش زنجیره ای پلیمراز رونویسی معکوسgreen fluorescent protein - پروتئین فلورسنت سبزMyelin basic protein - پروتئین پایه میلینPatched 1 - پچ 1protein gene product 9.5 - ژن پروتئین محصول 9.5trigeminal ganglion - گانگلیون سه گانه
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Activation of Shh signaling is known to be observed following injury of the peripheral nerves such as the sciatic nerve. However, the precise role of Shh signaling during peripheral nerve regeneration is not fully understood. The inferior alveolar nerve (IAN) is most commonly injured during oral surgery. Unlike the sciatic nerve, the IAN is isolated from other craniofacial tissues, as it resides in a long bony canal within the mandible. The IAN is thus an excellent experimental model for investigating peripheral nerve regeneration. In this study, the role of Shh signaling in peripheral nerve regeneration was investigated using the mouse IAN transection model. During regeneration, Shh signaling was activated within the entire distal region of the IAN and proximal stumps. Inhibition of Shh signaling by cyclopamine application at the transection site led to abnormal axon growth in random directions, a reduced number of macrophages, and an increase in myelin debris within the distal region. Shh signaling is thus involved in peripheral nerve regeneration via the regulation of myelin degradation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 671, 3 April 2018, Pages 114-119
Journal: Neuroscience Letters - Volume 671, 3 April 2018, Pages 114-119
نویسندگان
Yurie Yamada, Atsushi Ohazama, Takeyasu Maeda, Kenji Seo,