Keywords: Intestine; Hedgehog; Stroma; Inflammation; CXCL12; α-SMA; α smooth muscle actin; CXCL; C-X-C motif chemokine ligand; CXCR; C-X-C motif chemokine receptor; DMEM; Dulbecco's modified Eagle medium; DSS; dextran sodium sulfate; FCS; fetal calf serum; Gli; g
مقالات ISI (ترجمه نشده)
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Keywords: 5-FU; 5-Fluorouracil; ABCB5; ATP-binding cassette sub-family B member 5; ABCC2; ATP-binding cassette sub-family C member 2; ABCG2; ATP-binding cassette sub-family G member 2; ACs; Anthocyanins; ALDH; aldehyde dehydrogenase; AML; acute myeloid leukemia; AP
Keywords: Ext1; Osteochondroma; Heparan sulfates; Fgfr3; Wnt; β-Catenin; Ihh; Ptch1; Chondrocyte differentiation;
Keywords: FAP; fibroadipogenic progenitors; PAX7; paired box 7; MRF; myogenic regulatory factor; Hh; Hedgehog; MyoD1; myogenic differentiation 1; Smo; Smoothened; Gli1; Gli family zinc finger 1; Ptch1; Patched 1; rRNA; ribosomal ribonucleic acid; CAGGS; CMV early e
Keywords: Bloom syndrome; dyskeratosis congenita; genetic testing; Gorlin syndrome; Muir-Torre syndrome; nonmelanoma skin cancer; oculocutaneous albinism; Rothmund-Thomson syndrome; Werner syndrome; 5-FU; 5-fluorouracil; ADA1; adenosine deaminase 1; ADA-SCID; a
Keywords: A-bomb; atomic bomb; ATM; ataxia telangiectasia mutated; ATP; adenosine triphosphate; ATPase; adenosine triphosphatase; BER; base excision repair; Ca2+; calcium ions; CDKN1A; cyclin-dependent kinase inhibitor 1A; CHO; Chinese hamster ovary; COX-2; cycloox
Keywords: 4-HPR; N-(4-hydroxyphenyl)retinamide; 5â²-UTR; 5â²-untranslated region; 9-cis-RA; 9-cis retinoic acid; 9cUAB30; (2E,4E,6Z,8E)-8-(3â²,4â²-dihydro-1â²(2'H)-naphthalen-1â²-ylidene)-3,7-dimethyl-2,4,6-octatrienoic acid; Acitretin; (2E,4E,6E,8E)-9-(4-met
Keywords: LPC; liver progenitor cell; Hh; Hedgehog; SHH; Sonic Hedgehog; IHH; Indian Hedgehog; DHH; Desert Hedgehog; PTCH1; Patched 1; SMO; Smoothened; GLI; GLI-Kruppel family of transcription factors; GLI-A; GLI full-length activator; Pc; primary cilia; TAA; thioa
The expression of Shh, Ptch1, and Gli1 in the developing caudal spinal cord of fetal rats with ARMs
Keywords: Lumbosacral spinal cord; Shh; Ptch1; Gli1; Anorectal malformations;
Sinomenine reduces growth and metastasis of breast cancer cells and improves the survival of tumor-bearing mice through suppressing the SHh pathway
Keywords: Hh; Hedgehog; SMO; smoothened; Ptch1; Patched 1 receptor 1; SHh; sonic hedgehog; NF-κB; nuclear factor kappa-light-chain-enhancer of activated B cells; EMT; epithelial-mesenchymal transition; qPCR; quantitative polymerase chain reaction; IHC; hematoxylin
CCRK is a novel signalling hub exploitable in cancer immunotherapy
Keywords: 9G8; serine and arginine rich splicing factor 7; AKT; AKT serine/threonine kinase; AR; androgen receptor; ARE; androgen response element; ARG1; arginase 1; ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia and rad3-related protein; BMDC; mous
Human amyloid β peptide and tau co-expression impairs behavior and causes specific gene expression changes in Caenorhabditis elegans
Keywords: AD; Alzheimer's disease; Aβ; amyloid-β peptide; PTCH1; patched homolog 1; TBC1D16; the Rab GTPase activating protein; WDFY3; the WD repeat and FYVE domain-containing protein 3; ARFGEF2; ADP-ribosylation factor guanine nucleotide exchange factor 2; EBF1;
The Sonic Hedgehog signaling pathway regulates inferior alveolar nerve regeneration
Keywords: SC; Schwann cell; Shh; Sonic Hedgehog; Ptch1; patched 1; Smo; Smoothened; Gli; glioma-associated oncogene homolog; IAN; inferior alveolar nerve; GFP; green fluorescent protein; PGP9.5; protein gene product 9.5; FITC; fluoresceinisothiocyanate; MBP; myelin
Expression Undercurrents of Sonic Hedgehog in Colorectal and Pancreatic Cancers
Keywords: Colorectal cancer; CRC; Pancreatic cancer; PC; Sonic hedgehog; SHH; Indian hedgehog; IHH; Desert hedgehog; DHH; Bone morphogenetic protein; BMP; Transforming growth factor; TGFβ; Pancreatic intra epithelial lesions; PanIN; Pancreatic ductal adenocarcinom
MiR-155 targets PTCH1 to mediate endothelial progenitor cell dysfunction caused by high glucose
Keywords: Diabetic foot ulcer; High glucose; Endothelial progenitor cells; MiR-155; PTCH1;
SOX9 Transcriptionally Regulates mTOR-Induced Proliferation of Basal Cell Carcinomas
Keywords: 4E-BP; 4E binding protein; AKT; v-akt murine thymoma viral oncogene homolog; BCC; basal cell carcinoma; BCNS; basal cell nevus syndrome; CCND1; cyclin D1; GLI; glioma-associated oncogene homolog; HEK; human embryonic kidney; ITRA; itraconazole; mTOR; mamm
Sonic hedgehog regulates the pathfinding of descending serotonergic axons in hindbrain in collaboration with Wnt5a and secreted frizzled-related protein 1
Keywords: Shh; Sonic Hedgehog; Sfrp1; Secreted frizzled-related protein 1; PCP; planar cell polarity; 5-HT; 5-hydroxytryptamine; E10.5; Embryonic day 10.5; A-P; Anterior to posterior; Fzd3; Frizzled 3; DMSO; Dimethylsulfoxide; Ptch1; Patched 1; Smo; Smoothened; R4;
Transcriptome analysis identifies genes involved in sex determination and development of Xenopus laevis gonads
Keywords: Amh; Anti-Müllerian hormone; Bmp4; Bone morphogenetic protein 4; Dax1; Dosage-sensitive sex reversal, adrenal hypoplasia critical region, on chromosome X, gene 1; Dhh; Desert hedgehog; Dmrt1; Doublesex and mab-3 related transcription factor 1; DM-W; W-li
Wall paintings facies and their possible genetic correlates in the ancient Pompeii: A bio-anthropologic message from the past?
Keywords: AD; Anno Domini; NBCCS; Nevoid basal cell carcinoma syndrome; CT-scan; Computer tomography; Wall paintings portrait; Gorlin-Goltz syndrome; NBCCS; Skeletal anomalies; PTCH1; NBCCS history; Pompeii;
Skeletal stigmata as keys to access to the composite and ancient Gorlin-Goltz syndrome history: The Egypt, Pompeii and Herculaneum lessons
Keywords: NBCCS; nevoid basal cell carcinoma syndrome; BCC; basal cell carcinoma; AML; ameloblastoma; OKC; odontogenic keratocystic tumor; CT; computerized tomography; ICOB; Index Cranico of Broca; Gorlin-Goltz syndrome; NBCCS; Skeletal anomalies; PTCH1; NBCCS hi
Tea polyphenols epigallocatechin gallete and theaflavin restrict mouse liver carcinogenesis through modulation of self-renewal Wnt and hedgehog pathways
Keywords: HCC; hepatocellular carcinoma; NDEA; N-nitrosodiethyl amine; CD44; cluster of differentiation 44; sFRP1; secreted frizzled-related protein 1; APC; adenomatosis polyposis coli; Hh; hedgehog pathway; Gli1; glioma-associated oncogene homolog 1; SMO; smoothen
Evasion of Cell Senescence Leads to Medulloblastoma Progression
Keywords: medulloblastoma; sonic hedgehog; ptch1; preneoplasia; cerebellum; p53; p16ink4a
Somatic copy number losses on chromosome 9q21.33q22.33 encompassing the PTCH1 loci associated with cardiac fibroma
Keywords: Somatic copy number loss; 9q21.33q22.33; Cardiac fibroma; PTCH1
Underestimated PTCH1 mutation rate in sporadic keratocystic odontogenic tumors
Keywords: KCOTs; keratocystic odontogenic tumors; NBCCS; nevoid basal cell carcinoma syndrome; PTCH1; the protein patched homolog 1 gene; BCCs; basal cell carcinomas; HH; Hedgehog; SSD; sterol-sensing domain; SHH; Sonic Hedgehog; PTCH1; Mutation; Keratocystic odont
Ribosomal protein S3 regulates GLI2-mediated osteosarcoma invasion
Keywords: RPS3; ribosomal protein S3; PTCH1; Patched1; SMO; Smoothened; SUFU; suppressor of fused; GLI; glioma-associated oncogene homolog; DMEM; Dulbecco's modified Eagle's medium; FBS; fetal bovine serum; NHOst; normal human osteoblast cells; RNAi; RNA interferen
Targeting cancer stem cells in solid tumors by vitamin D
Keywords: CSC; Cancer stem cell; 1α,25(OH)2D3; 1α,25-dihydroxyvitamin D3; EpCAM; Epithelial cell adhesion molecule; PROM1; Prominin 1; CXCR4; C-X-C chemokine receptor type 4; SDF1; Stromal cell-derived factor 1; ALDH-1; Aldehyde dehydrogenease-1; EMT; Epithelial-
Smoothened (SMO) receptor mutations dictate resistance to vismodegib in basal cell carcinoma
Keywords: Basal cell carcinoma; Hedgehog pathway; PTCH1; SMO; Vismodegib; Primary resistance; Secondary resistance;
Resveratrol and curcumin synergistically induces apoptosis in cigarette smoke condensate transformed breast epithelial cells through a p21Waf1/Cip1 mediated inhibition of Hh-Gli signaling
Keywords: MCF-10A-Tr; Curcumin; Resveratrol; Combination therapy; Hh-Gli Signaling; p21Waf/Cip1; CSC; cigarette smoke condensate; MCF-10A-Tr; Cigarette smoke condensate mediated MCF-10A transformed cells; MTT; [3-(4, 5-dimethylthiazol-2yl-)-2, 5-diphenyl tetrazoliu
Molecular cross talk between Notch1, Shh and Akt pathways during erythroid differentiation of K562 and HEL cell lines
Keywords: NICD; Notch1 intracellular domain; Shh; Sonic Hedgehog; GSI; Gamma secretase inhibitor; DNCSL; Dominant negative CSL; Ptch1; Patched1; Smo; Smoothened; myr-Akt; myristoylated-Akt; Gli; Glioma-associated oncogene homologue; Notch1; Erythropoiesis; Shh; Akt
Inhibition of hedgehog signaling by GANT58 induces apoptosis and shows synergistic antitumor activity with AKT inhibitor in acute T cell leukemia cells
Keywords: T-ALL; GLI1; GANT58; AKT inhibitor; Apoptosis; Hh; hedgehog; T-ALL; acute T cell leukemia; SMO; Smoothened; GLI1; GLI family zinc finger 1; SHH; Sonic hedgehog; DHH; Desert hedgehog; IHH; Indian hedgehog; PTCH1; Patched 1; PI3K; phosphatidylinositol 3-kin
In Vivo Mn-Enhanced MRI for Early Tumor Detection and Growth Rate Analysis in a Mouse Medulloblastoma Model
Keywords: 2D; two-dimensional; 3D; three-dimensional; Cb; cerebellum; CKO; conditional knockout; GCP; granule cell precursor; IHC; immunohistochemistry; MB; medulloblastoma; MEMRI; Mn-enhanced MRI; Mn; manganese; MRI; magnetic resonance imaging; Ptch1; Patched-1; S
New advances of DNA methylation in liver fibrosis, with special emphasis on the crosstalk between microRNAs and DNA methylation machinery
Keywords: miRNAs; small non-coding RNAs; HSC; hepatic stellate cell; ECM; extracellular matrix; α-SMA; α-smooth muscle actin; TGF-β; transforming growth factor-β; PDGF; platelet-derived growth factor; FGF; fibroblast growth factor; ICAM-1; intercellular adhesio
Unicystic ameloblastoma associated with the novel K729M PTCH1 mutation in a patient with nevoid basal cell carcinoma (Gorlin) syndrome
Keywords: PTCH1; nevoid basal cell carcinoma syndrome; Gorlin syndrome; unicystic ameloblastoma; keratocystic odontogenic tumors
Intraepithelial paracrine Hedgehog signaling induces the expansion of ciliated cells that express diverse progenitor cell markers in the basal epithelium of the mouse mammary gland
Keywords: Mouse mammary gland; Hedgehog; Paracrine; Intraepithelial; Primary cilia; Progenitor cell; Ptch1
The estrogen receptor beta agonist diarylpropionitrile (DPN) inhibits medulloblastoma development via anti-proliferative and pro-apototic pathways
Keywords: Ptch1; DPN; PPT; 17β-Estradiol; Radiation
Association of Copy Number Loss of CDKN2B and PTCH1 With Poor Overall Survival in Patients With Pulmonary Squamous Cell Carcinoma
Keywords: CDKN2B; Copy number alteration; PTCH1; Pulmonary squamous cell carcinoma; Survival
Patched1 haploinsufficiency impairs ependymal cilia function of the quaking viable mice, leading to fatal hydrocephalus
Keywords: qkv; quaking viable; Shh; sonic hedgehog; ptch1; patched1; pacrg; parkin-coregulated gene; CSF; cerebrospinal fluid; CBF; cilia beat flow; Hydrocephalus; Patched1; Quaking viable mice; Cilia;
Hedgehog signaling in skin cancers
Keywords: Hedgehog; Smoothened; PTCH1; Skin cancer; Signal transduction; Therapy
Involvement of PTCH1 mutations in the calcifying epithelial odontogenic tumor
Keywords: Calcifying epithelial odontogenic tumor; PTCH1; Gli1; Gli2; SHH; Sequencing; Immunohistochemistry
Loss of Indian Hedgehog Activates Multiple Aspects of a Wound Healing Response in the Mouse Intestine
Keywords: Indian Hedgehog; Intestine; Regeneration; Inflammation; α-Sma; α-smooth muscle actin; Bmp; bone morphogenetic protein; BrdU; bromodeoxyuridine; Gli; glioma-associated oncogene; Hh; Hedgehog; Hhip; Hedgehog-interacting protein; HRP; horseradish peroxidas
PTCH1 mutations in odontogenic keratocysts: Are they related to epithelial cell proliferation?
Keywords: PTCH1; Odontogenic keratocyst; Nevoid basal cell carcinoma syndrome; Ki67; Cell proliferation
Overexpression of hedgehog pathway molecules and FOXM1 in non-small cell lung carcinomas
Keywords: HH, hedgehog; NSCLC, non-small cell lung cancer; FOXM1, Forkhead Box M1; SHH, sonic hedgehog; PTCH1, patched1; SMO, Smoothened; SCLC, small cell lung cancer; SuFu, suppressor of fusedGLI; FOXM1; Hedgehog; NSCLC; PTCH1; SHH; SMO
Sonic hedgehog signalling inhibits palatogenesis and arrests tooth development in a mouse model of the nevoid basal cell carcinoma syndrome
Keywords: Sonic hedgehog; Nevoid basal cell carcinoma syndrome; Cleft palate; Hypertelorism; Hypodontia; Craniofacial development; Ptch1; Gli1; Transgenic; Keratin-14;
Disp1 regulates growth of mammalian long bones through the control of Ihh distribution
Keywords: Disp1; Dispatched1; Ihh; Indian hedgehog; N-Shh; non-cholesterol modified Sonic hedgehog; PTHrP; parathyroid hormone related peptide; Shh; sonic hedgehog; Ptch1; Patched1; Smo; Smoothened; PPR; Parathyroid hormone-PTHrP receptor; Disp2; Dispatched2; Disp1