کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8436212 | 1546779 | 2018 | 35 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Transcriptome analysis identifies genes involved in sex determination and development of Xenopus laevis gonads
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کلمات کلیدی
WT1FollistatinDMRT1emx2PDGFRαGATA4PTCH1GATA binding protein 4DHHWNT4FGF9InhibinSF1FGFR2NR5A1DAX1PDGFRspo1Wilms tumor 1BMP4FSTForkhead box L2foxl2R-spondin 1PTGDSSOx - SOXAMH - اوTestis - بیضهOvary - تخمدانSex determination - تعیین جنسیتGonad development - توسعه گنادDesert Hedgehog - خارپشت بیابانStar - ستارهSteroidogenic factor 1 - عامل استروئیدوژنیک 1Fibroblast growth factor 9 - عامل رشد فیبروبلاست 9platelet-derived growth factor - فاکتور رشد حاصل از پلاکتdoublesex and mab-3 related transcription factor 1 - فاکتور رونویسی مرتبط دوبعدی و موب 3Xenopus - قورباغه پنجه دارAnti-Müllerian hormone - هورمون Anti-MellerianSteroidogenic acute regulatory protein - پروتئین حاکم استروئیدوژنیک حادbone morphogenetic protein 4 - پروتئین مورفوژنیک استخوان 4Prostaglandin D synthase - پروستاگلاندین D سنتازPatched 1 - پچ 1Gonad - گنادplatelet-derived growth factor receptor α - گیرنده عامل فاکتور رشد فاکتور αfibroblast growth factor receptor 2 - گیرنده فاکتور رشد فیبروبلاست 2
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Development of the gonads is a complex process, which starts with a period of undifferentiated, bipotential gonads. During this period the expression of sex-determining genes is initiated. Sex determination is a process triggering differentiation of the gonads into the testis or ovary. Sex determination period is followed by sexual differentiation, i.e. appearance of the first testis- and ovary-specific features. In Xenopus laevis W-linked DM-domain gene (DM-W) had been described as a master determinant of the gonadal female sex. However, the data on the expression and function of other genes participating in gonad development in X. laevis, and in anurans, in general, are very limited. We applied microarray technique to analyze the expression pattern of a subset of X. laevis genes previously identified to be involved in gonad development in several vertebrate species. We also analyzed the localization and the expression level of proteins encoded by these genes in developing X. laevis gonads. These analyses pointed to the set of genes differentially expressed in developing testes and ovaries. Gata4, Sox9, Dmrt1, Amh, Fgf9, Ptgds, Pdgf, Fshr, and Cyp17a1 expression was upregulated in developing testes, while DM-W, Fst, Foxl2, and Cyp19a1 were upregulated in developing ovaries. We discuss the possible roles of these genes in development of X. laevis gonads.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Differentiation - Volume 100, MarchâApril 2018, Pages 46-56
Journal: Differentiation - Volume 100, MarchâApril 2018, Pages 46-56
نویسندگان
Rafal P. Piprek, Milena Damulewicz, Malgorzata Kloc, Jacek Z. Kubiak,