کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8841899 | 1615034 | 2018 | 27 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of the antidepressant mirtazapine and zinc on nicotinic acetylcholine receptors
ترجمه فارسی عنوان
اثرات میترازاپین و روی داروهای ضد افسردگی بر گیرنده های استیل کولین نیکوتین
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
Nicotinic acetylcholine receptors (nAChRs) and zinc are associated with regulation of mood and related disorders. In addition, several antidepressants inhibit muscle and neuronal nAChRs and zinc potentiates inhibitory actions of them. Moreover, mirtazapine (a noradrenergic, serotonergic and histaminergic antidepressant) inhibits muscarinic AChRs and its effects on nAChRs are unknown. Therefore, we studied the modulation of muscle α1β1γd nAChRs expressed in oocytes and native α7-containing nAChRs in hippocampal interneurons by mirtazapine and/or zinc, using voltage-clamp techniques. The currents elicited by ACh in oocytes (at â60â¯mV) were similarly inhibited by mirtazapine in the absence and presence of 100â¯Î¼M zinc (IC50 â¼15â¯Î¼M); however, the ACh-induced currents were stronger inhibited with 20 and 50â¯Î¼M mirtazapine in the presence of zinc. Furthermore, the potentiation of ACh-induced current by zinc in the presence of 5â¯Î¼M mirtazapine was 1.48â¯Â±â¯0.06, and with 50â¯Î¼M mirtazapine zinc potentiation did not occur. Interestingly, in stratum radiatum interneurons (at â70â¯mV), 20â¯Î¼M mirtazapine showed less inhibition of the current elicited by choline (Ch) than at 10â¯Î¼M (0.81â¯Â±â¯0.02 and 0.74â¯Â±â¯0.02 of the Ch-induced current, respectively). Finally, the inhibitory effects of mirtazapine depended on membrane potential: 0.81â¯Â±â¯0.02 and 0.56â¯Â±â¯0.05 of the control Ch-induced current at â70 and â20â¯mV, respectively. These results indicate that mirtazapine interacts with muscle and neuronal nAChRs, possibly into the ion channel; that zinc may increase the sensitivity of nAChRs to mirtazapine; and that mirtazapine decreases the sensitivity of nAChRs to zinc.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 665, 5 February 2018, Pages 246-251
Journal: Neuroscience Letters - Volume 665, 5 February 2018, Pages 246-251
نویسندگان
Andy Hernández-Abrego, Elizabeth Vázquez-Gómez, Jesús GarcÃa-Colunga,