کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8841962 1615036 2018 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Beyond the critical point: An overview of excitotoxicity, calcium overload and the downstream consequences
ترجمه فارسی عنوان
فراتر از نقطه بحرانی: یک مرور کلی از مسمومیت زیستی، اضافه بار کلسیم و عواقب آن در پایین دست
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی
Over the past several decades, an overwhelming body of research has greatly expanded our understanding of the mechanisms underlying excitotoxicity in brain ischemia as well as in many chronic neurodegenerative diseases. The identification of an array of molecular targets has opened avenues for neuroprotective strategies and, consequently, has sparked considerable interest for their attractive therapeutic means as pharmacological options. The purpose of this work is to provide a general overview of neuronal excitotoxicity and the inevitable downstream consequences of Ca2+ overload. We also discuss the contribution of Ca2+ transporters in excitotoxicity. This article is part of a Special Issue entitled “Calcium Pumps and Exchangers in Neuronal Injury and Neurodegeneration”.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 663, 10 January 2018, Pages 79-85
نویسندگان
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