کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8850083 | 1618663 | 2017 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
In silico analysis of glycinamide ribonucleotide transformylase inhibition by PY873, PY899 and DIA
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
GARglycinamide ribonucleotidedhfr - Dhfrisophthalic acid - اسید ایزوفاتیکAIRS - ایرسInhibition - بازداریGARS - بچه هاGlycinamide ribonucleotide transformylase - ترانسلوازاز ریبونوکلئوتید گلیسینامیدIn silico - درون رایانهای، این سیلیکوdihydrofolate reductase - دی هیدروفلات ردوکتازDIA - روزGART - گارت
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بوم شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
In humans, purine de novo synthesis pathway consists of multi-functional enzymes. Nucleotide metabolism enzymes are potential drug targets for treating cancer and autoimmune diseases. Glycinamide ribonucleotide transformylase (GART) is one of the most important trifunctional enzymes involved in purine synthesis. Previous studies have demonstrated the role of folate inhibitors against tumor activity. In this present study, three components of GART enzyme were targeted as receptor dataset and in silico analysis was carried out with folate ligand dataset. To accomplish the task, Autodock 4.2 was used for determining the docking compatibilities of ligand and receptor dataset. Taken together, it has been suggested that folate ligands could be potentially used as inhibitors of GART.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Saudi Journal of Biological Sciences - Volume 24, Issue 6, September 2017, Pages 1155-1161
Journal: Saudi Journal of Biological Sciences - Volume 24, Issue 6, September 2017, Pages 1155-1161
نویسندگان
Sidra Batool, Muhammad Sulaman Nawaz, Gohar Mushtaq, Fahed Parvaiz, Mohammad A. Kamal,