Di (2-ethyl hexyl) phthalate (DEHP)-induced kidney injury in quail (Coturnix japonica) via inhibiting HSF1/HSF3-dependent heat shock response

Di (2-ethyl hexyl) phthalate (DEHP) exposure induced the toxic effects of kidney and destroyed the pathophysiological integrity of the kidney in quail. Our findings provide evidence that DEHP-induced nephrotoxicity is associated with heat-shock response (HSR). DEHP exposure activated the HSR signaling pathway to prevent the toxicity in the kidney.199