کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8850928 1618765 2018 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Transcriptomic and methylomic analysis reveal the toxicological effect of 2,3,7,8-Tetrachlorodibenzodioxin on human embryonic stem cell
ترجمه فارسی عنوان
تجزیه و تحلیل ترانسکتومیک و متیومومیک اثرات سمی 2،3،7،8-تتراکلرویدی دی بنزودیویکسین بر روی سلول های بنیادی جنینی انسان را نشان می دهد
کلمات کلیدی
دیوکسین، تجزیه و تحلیل توکسوژنومیک، سلول های بنیادی جنینی، ترانسکتیکوم متولیوم،
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست شیمی زیست محیطی
چکیده انگلیسی
Cumulating epidemiological studies demonstrated that environmental exposure to endocrine disrupting chemicals (EDCs) during the early stages of fetal development is associated with the increase in disease susceptibility in later life. The fetal developmental plasticity is considered as a protective mechanism against an undesirable prenatal environment. Dioxin is one of the environmental contaminants and is considered a diabetogenic factor. Experimental animal and human epidemiological studies have revealed that dioxin exposure was associated with insulin resistance and altered beta cell function. But the effect of dioxin exposure in early stage of fetal development is still largely unknown. In this report, we used the human embryonic stem cell (hESC) line, VAL-3, as a model, together with Methyl-CpG Binding Domain (MBD) protein-enriched genome sequencing and transcriptome sequencing (RNA-seq), in order to determine the dynamic changes of the epigenetic landscape and transcriptional dysregulation in hESC upon dioxin exposure. The bioinformatics analyses including the Database for Annotation, Visualization and Integrated Discovery (DAVID) analysis and Ingenuity Pathway Analysis (IPA) highlighted the predisposed neural, hepatic, cardiac and metabolic toxicological effects of dioxin during the fetal development.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemosphere - Volume 206, September 2018, Pages 663-673
نویسندگان
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