کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8851803 | 1618772 | 2018 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
DNA damage in a liver tissue of metal exposed Clethrionomys glareolus
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
شیمی زیست محیطی
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چکیده انگلیسی
It is widely known that some toxic agents may act on DNA strand resulting in its damages. One of the possible impairments is formation of abasic sites in DNA. The aim of this study was to indicate a presence of these DNA sites in the liver tissue of bank voles inhabiting the vicinity of zinc/lead smelters. Samples that were used originated from animals collected from unpolluted (NiepoÅomice, TeleÅnica Oszwarowa, MikoÅajki) and polluted (Miasteczko ÅlÄ
skie, Katowice, Olkusz) populations. They significantly differed in terms of tissue lead concentrations in the kidney and liver. The means of detected AP sites per 105 bp ranged between 3.39 (TeleÅnica Oszwarowa) to 5.13 (Miasteczko ÅlÄ
skie). Statistical analysis (ANOVA) showed no difference in terms of number of the AP sites between single populations. However, t-test showed significant difference between the unpolluted and polluted populations. Factorial ANOVA indicated that sex is not a factor influencing the number of AP sites. The analyses revealed statistically significant relationships between the number of AP sites and Cu concentrations in the liver, and also Pb and Cd concentrations in the kidney.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemosphere - Volume 199, May 2018, Pages 625-629
Journal: Chemosphere - Volume 199, May 2018, Pages 625-629
نویسندگان
Magdalena Mikowska, Renata Åwiergosz-Kowalewska,