کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8853263 | 1618902 | 2018 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Toxicity of imidazoles ionic liquid [C16mim]Cl to Hela cells
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
شیمی زیست محیطی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Toxicity of imidazoles ionic liquid [C16mim]Cl to Hela cells Toxicity of imidazoles ionic liquid [C16mim]Cl to Hela cells](/preview/png/8853263.png)
چکیده انگلیسی
Our study aimed to evaluate the toxicity of 1-hexadecyl-3-methylimidazolium chloride ([C16min]Cl) on the human cervical carcinoma (Hela) cells. We evaluated toxicity, cell viability, genotoxicity, oxidative stress, apoptosis, and apoptosis-related gene expression in Hela cells following exposure to [C16min]Cl. The results indicated that [C16min]Cl inhibited the growth of Hela cells, decreased cell viability, induced DNA damage and apoptosis, inhibited superoxide dismutase, decreased glutathione content, as well as increased the cellular malondialdehyde level of Hela cells. Moreover, [C16min]Cl induced changes in the transcription of p53, Bax and Bcl-2, suggesting that the p53 and Bcl-2 family might have been involved in the cytotoxicity and apoptosis induced by [C16min]Cl in Hela cells. Taken together, these results revealed that [C16min]Cl imparts oxidative stress, genotoxicity, and induces apoptosis in Hela cells; hence, it is not a green solvent.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ecotoxicology and Environmental Safety - Volume 162, 30 October 2018, Pages 408-414
Journal: Ecotoxicology and Environmental Safety - Volume 162, 30 October 2018, Pages 408-414
نویسندگان
Xiaohua Xia, Ruyan Wan, Peijin Wang, Weiran Huo, Hui Dong, Qiyan Du,