کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8854659 1618916 2018 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
MicroRNAs and their role on fish oxidative stress during xenobiotic environmental exposures
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست شیمی زیست محیطی
پیش نمایش صفحه اول مقاله
MicroRNAs and their role on fish oxidative stress during xenobiotic environmental exposures
چکیده انگلیسی
There is a growing global concern about the health implications of xenobiotics, which have harmful effects to both humans and wildlife. Among them, teleost fish are known as very sensitive to anthropogenic impacts, and are often being used as sentinel species in the aquatic environment. Xenobiotic molecules can alter the physiological homeostasis of fish and trigger an oxidative stress through overproduction of reactive oxygen species (ROS), suppressing the antioxidant system (AS) activity. An overwhelming generation of ROS is usually accompanied by damage to lipids, proteins and DNA structure, which can be associated with mutations, chromosomal aberrations and carcinogenesis. In particular, more attention has been paid lately to transcriptional and posttranscriptional regulation by several genes and microRNAs (miRNAs) related to AS after xenobiotic exposure in fish. Revealing these molecular mechanisms will help better understanding the processes of detoxification of xenobiotics and resistance to stress, and can also provide valuable information for estimating risk assessment of environmental pollution.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ecotoxicology and Environmental Safety - Volume 148, February 2018, Pages 995-1000
نویسندگان
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