کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8877003 | 1623979 | 2018 | 19 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Stability analysis of the Michaelis-Menten approximation of a mixed mechanism of a phosphorylation system
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم کشاورزی و بیولوژیک (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Stability analysis of the Michaelis-Menten approximation of a mixed mechanism of a phosphorylation system Stability analysis of the Michaelis-Menten approximation of a mixed mechanism of a phosphorylation system](/preview/png/8877003.png)
چکیده انگلیسی
In this paper, we consider a mixed mechanism of a n-site phosphorylation system in which the mechanism of phosphorylation is distributive and that of dephosphorylation is processive. It is assumed that the concentrations of the substrates are much higher than those of the enzymes and their intermediate complexes. This assumption enables us to reduce the system using the steady-state approach to a Michaelis-Menten approximation of the system. It is proved that the resulting system of nonlinear ordinary differential equations admits a unique positive equilibrium in every positive stoichiometric compatibility class using the theory of quadratic equations. We then consider two special cases. In the first case, we assume that the Michaelis constants associated with the different substrates in the phosphorylation reactions are equal and construct a Lyapunov function to prove asymptotic stability of the system. In the second case, we assume that there are just two sites of phosphorylation and dephoshorylation and prove that the resulting system is asymptotically stable using Poincare´ Bendixson theorem.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mathematical Biosciences - Volume 301, July 2018, Pages 159-166
Journal: Mathematical Biosciences - Volume 301, July 2018, Pages 159-166
نویسندگان
Shodhan Rao,