کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8917567 | 1642773 | 2018 | 20 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Nanopore confinement for electrochemical sensing at the single-molecule level
ترجمه فارسی عنوان
محصور نانوپور برای سنجش الکتروشیمیایی در سطح تک مولکول
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
الکتروشیمی
چکیده انگلیسی
Single-molecule sensing opens avenues of studying the population heterogeneities and the conformational dynamics of system ranging from single DNAs to single proteins. Nanopores providing the electrochemically confined space for accommodation of single analytes, directly convert the single-molecule behaviors into the measurable electrochemical read-outs with high signal-to-noise ratio. A good volume of researches exists on nanopore-based electrochemical detection ranging from nucleic acids, peptides, proteins, and biomolecular complexes to organic polymers and small molecules. Due to the advantage of nanopore confinement, new sensing mechanisms have been reported to shed light on single-molecule structure and activity correlation. In this review, we provide an overview of the electrochemically confined effects in a nanopore on the aspects ranging from single-molecule volume exclusion, redox process confinement, and electromagnetic field enhancement. The electrochemically confined effects would provide nanopore a series of vivid and exciting discoveries in single-molecule analysis of biological processes and chemical reactions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Electrochemistry - Volume 7, January 2018, Pages 172-178
Journal: Current Opinion in Electrochemistry - Volume 7, January 2018, Pages 172-178
نویسندگان
Yao Lin, Yi-Lun Ying, Yi-Tao Long,