کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8918970 1642864 2018 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Engineering perfused microvascular networks into microphysiological systems platforms
ترجمه فارسی عنوان
مهندسی شبکه های میکروواسکولار به سیستم های میکرو فیزیولوژی سیستم ها
موضوعات مرتبط
مهندسی و علوم پایه سایر رشته های مهندسی مهندسی پزشکی
چکیده انگلیسی
The microvasculature is an essential component of nearly all tissues, with most cells residing within 200 μm of a vessel. Endothelial cells form the inner wall of microvessels and control which nutrients, cells and drugs cross into the underlying tissue. Given these critical roles, it makes sense to include functioning microvessels when creating tissue models, and these can be generated by pre-patterning of channels, 3D printing, or by “biology-directed” vasculogenesis and angiogenesis. These methods have been used to create tissue-specific vascularized micro-organs, vascularized microtumors, and vascular beds for studying tumor cell and immune cell extravasation. Recent innovations in 3D printing and high-throughput technologies have enabled more complex geometries and facilitated more comprehensive studies. Future developments hold promise for increasingly relevant models of healthy and diseased tissues, with implications for studying biological mechanisms and screening for new drugs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Biomedical Engineering - Volume 5, March 2018, Pages 74-81
نویسندگان
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