کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8925918 | 1643639 | 2018 | 18 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Extracellular vesicles in non-alcoholic and alcoholic fatty liver diseases
ترجمه فارسی عنوان
حامل های خارج سلولی در بیماری های کبدی چربی غیر الکلی و الکلی
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کبدشناسی
چکیده انگلیسی
Fatty liver diseases, non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD) are the most common causes of chronic liver diseases around the world. NAFLD and ALD can progress towards a more severe form of the disease, including as non-alcoholic steatohepatitis (NASH) and alcoholic steatohepatitis (ASH). In both instances central pathogenic events include hepatocyte death, liver inflammation, pathological angiogenesis, and fibrosis, followed by cirrhosis and cancer. Over the last few years, extracellular vesicles (EVs) have been identified as effective cell-to-cell communicators that contain a cell- and stress-specific cargo from the cell of origin and are capable of transferring this cargo to a target or acceptor cell. In this review, we focus on the growing evidence supporting a role for EVs in the pathophysiology of NASHÂ and ASH as well as their potential roles as targets for novel biomarkers for these conditions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Liver Research - Volume 2, Issue 1, March 2018, Pages 30-34
Journal: Liver Research - Volume 2, Issue 1, March 2018, Pages 30-34
نویسندگان
Akiko Eguchi, Ariel E. Feldstein,