کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8932061 | 1644550 | 2015 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of combining tramadol and morphine in adult surgical patients: a systematic review and meta-analysis of randomized trials
ترجمه فارسی عنوان
اثر ترکیب ترامادول و مورفین در بیماران جراحی بالغ: یک بررسی سیستماتیک و متاآنالیز آزمایشات تصادفی
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کلمات کلیدی
ضد درد متاآنالیز، درد بعد از عمل، عمل جراحی، ترامادول،
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیهوشی و پزشکی درد
چکیده انگلیسی
The role for tramadol in multimodal postsurgical analgesic strategies remains unclear. We undertook a systematic review to evaluate the utility of combining tramadol with morphine after surgery. We searched the MEDLINE, EMBASE, LILAC, Cochrane, and Clinical Trial Register databases for randomized, controlled studies comparing tramadol with placebo or active control in patients undergoing surgery. Fourteen studies (713 patients) were included. There was a limited but significant postoperative morphine-sparing effect, with a weighted mean difference (WMD) of â6.9 (95% confidence interval â11.3 to â2.5) mg. This effect was not associated with a decrease in morphine-related adverse effects. No difference in the incidence of nausea, vomiting, sedation, or shivering was observed. There was no decrease in pain intensity at 24 h; the WMD was â0.9 (â7.2; 5.2) on a 100 mm visual analogue scale at 24 h. We found no significant clinical benefit from the combination of i.v. tramadol and morphine after surgery.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: British Journal of Anaesthesia - Volume 114, Issue 3, March 2015, Pages 384-395
Journal: British Journal of Anaesthesia - Volume 114, Issue 3, March 2015, Pages 384-395
نویسندگان
V. Martinez, L. Guichard, D. Fletcher,