Effects of chitosan and chitosan N-acetylcysteine solutions on conjunctival epithelial cells

Results demonstrated that chitosan is taken up into conjunctival epithelial cells in vitro and in vivo, therefore fulfilling some of the requirements of an adjuvant for conjunctival mucosal vaccines. C-NAC is also well tolerated but not taken up by cells, making it a good candidate for ocular formulations supposed to persist on the ocular surface for an extended period of time.