کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8941289 | 1644994 | 2018 | 30 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Non-immunoglobulin scaffold proteins: Precision tools for studying protein-protein interactions in cancer
ترجمه فارسی عنوان
پروتئینهای داربست غیر ایمونوگلوبولین: ابزار دقیق برای مطالعه اثر متقابل پروتئین و پروتئین در سرطان
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موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بیو مهندسی (مهندسی زیستی)
چکیده انگلیسی
Cancer is frequently characterised by dysregulation of the cellular signalling processes that govern proliferation, survival and attachment. Understanding such dysregulation continues to present a challenge given the importance of protein-protein interactions in intracellular processes. Exploring this protein-protein interactome requires novel tools capable of discriminating between highly homologous proteins, individual domains and post-translational modifications. This review examines the potential of scaffold-based binding proteins to fulfil these requirements. It also explores protein-protein interactions in the context of intracellular signalling pathways and cancer, and demonstrates the uses of scaffold proteins as functional moderators, biosensors and imaging reagents. This review also highlights the timeliness and potential to develop international consortia to develop and validate highly specific “proteome” scaffold-based binding protein reagents with the ultimate aim of developing screening tools for studying the interactome.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: New Biotechnology - Volume 45, 25 October 2018, Pages 28-35
Journal: New Biotechnology - Volume 45, 25 October 2018, Pages 28-35
نویسندگان
Heather L. Martin, Robert Bedford, Sophie J. Heseltine, Anna A. Tang, Katarzyna Z. Haza, Ajinkya Rao, Michael J. McPherson, Darren C. Tomlinson,