کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8941703 1645015 2018 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Can measuring hippocampal atrophy with a fully automatic method be substantially less noisy than manual segmentation over both 1 and 3 years?
ترجمه فارسی عنوان
آیا می توان اندازه گیری آتروفی هیپوکامپ را با یک روش کاملا اتوماتیک به میزان قابل توجهی کمتر از بخش بندی دستی در طی 1 و 3 سال انجام داد؟
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
چکیده انگلیسی
To quantify the “segmentation noise” of several widely used fully automatic methods for measuring longitudinal hippocampal atrophy in Alzheimer's disease and compare the results to the segmentation noise of manual segmentation over both 1 and 3 years. The segmentation noise of 5 longitudinal hippocampal atrophy measurement methods was quantified, including checking its Gaussianity, using 264 subjects from the ADNI1 back-to-back (BTB) data set over both 1 year and 3 year intervals. The segmentation methods were FreeSurfer 5.3.0 both cross sectional and longitudinal, FreeSurfer 6.0.0 longitudinal, MAPS-HBSI and FSL/FIRST 5.0.8. The BTB manual segmentation of 75 ADNI subjects from a previous study provided the manual distributions for comparison. All methods, including the manual segmentation, violated the Gaussianity assumption. Two methods, FreeSurfer 6.0.0 and MAPS-HBSI, had a segmentation noise substantially less than a surrogate for manual segmentation. FreeSurfer 5.3.0 longitudinal was confirmed as a surrogate for manual segmentation. The violation of the Gaussian assumption by the segmentation methods assessed, including manual, suggests results of previous studies that assumed Gaussian statistics without confirmation may need review. Fully automatic FreeSurfer 6.0.0 and MAPS-HBSI both have lower segmentation noise than manual requiring less than two thirds of the subjects to detect the same treatment effect.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research: Neuroimaging - Volume 280, 30 October 2018, Pages 39-47
نویسندگان
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