کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8942934 | 1645123 | 2018 | 27 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
In vitro bioactivity and cytotoxicity of films based on mesocarp of Orbignya sp. and carboxymethylcellulose as a tannic acid release matrix
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
This study aims to obtain mesocarp films of Orbignya sp. (MB) and carboxymethylcellulose (CMC) for application as a drug release matrix. Tannic acid (TA) was used as a standard drug. The films were evaluated by infrared, swelling power, TA release profile, bioactivity and in vitro cytotoxicity. Infrared results indicated absorption at 1.205âcmâ1, which is characteristic of ester group from the incorporated tannin. The MB-CMC film had 449.15% swelling power, release of 71.01% of TA of the matrix after 24âh. Films showed scavenger activity of radicals DPPH (79.07â±â1.71% to 82.17â±â1.94%) and ABTS+ (82.20â±â0.30% to 88.90â±â1.05). The MB-CMC film also showed in vitro cytotoxicity on sarcoma-180 (91.86â±â9.97%) and on promastigote forms of Leishmania major (100%). Polymers showed good compatibility in the mixture and the results suggest the films obtained are promising as drug release matrices.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 201, 1 December 2018, Pages 113-121
Journal: Carbohydrate Polymers - Volume 201, 1 December 2018, Pages 113-121
نویسندگان
Antonia de Sousa Leal, Ricardo de Araújo, Grasielly Rocha Souza, Gláucia LaÃs Nunes Lopes, Sean Telles Pereira, Michel Muálem de Moraes Alves, Humberto Medeiros Barreto, André LuÃs Menezes Carvalho, Paulo Michel Pinheiro Ferreira, Davi Silva,