Covalent inhibitors of nicotinamide N-methyltransferase (NNMT) provide evidence for target engagement challenges in situ

Covalent inhibitors of nicotinamide N-methyltransferase (NNMT) provide evidence for target engagement challenges in situ

Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 28, Issue 16, 1 September 2018, Pages 2682-2687

Hsin-Yu Lee, Radu M. Suciu, Benjamin D. Horning, Ekaterina V. Vinogradova, Olesya A. Ulanovskaya, Benjamin F. Cravatt,