کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8957760 1646226 2018 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Emerging immunotherapeutic strategies targeting telomerases in genitourinary tumors
ترجمه فارسی عنوان
استراتژی های جدید ایمن سازی درمان با هدف تلومراز در تومورهای تناسلی
کلمات کلیدی
سرطان مثانه، ایمونوتراپی، سرطان پروستات، سرطان کلیه، تلومراز،
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی هماتولوژی
چکیده انگلیسی
Telomerase activity and telomere length are essential for the pathogenesis of several human diseases, including genitourinary tumors. Telomerase constitutes a complex system that includes human telomerase reverse transcriptase (hTERT), human telomerase RNA component (hTR) and telomerase associated protein 1 (TEP1), which are overexpressed in tumor cells compared to normal cells and are involved in the carcinogenesis and progression of renal cell carcinoma (RCC), bladder (BC) and prostate cancer (PCa). In addition, telomerase degraded peptide fragments expressed on the surface of tumor cells lead to their recognition by immune cells. On this scenario, in vitro and in vivo studies have shown effective anti-tumor activity of hTERT-tailored strategies in genitourinary tumors, including active immunotherapy with hTERT-peptide vaccines and passive immunotherapy with hTERT-transduced T cell infusion. This review emphasizes the role of telomerase in the carcinogenesis and progression of genitourinary tumors, thus underlying the potential of emerging telomerase-tailored immunotherapies in these patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Critical Reviews in Oncology/Hematology - Volume 131, November 2018, Pages 1-6
نویسندگان
, , , , , , , , ,