کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8963223 | 1646609 | 2018 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
HFpEF, a Disease of the Vasculature: A Closer Look at the Other Half
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کلمات کلیدی
PKGMLCKMLCPMYPT1HFrEFHFpEFRLCpKaPDEcGMPcAMP - cAMPcyclic adenosine 3′,5′-monophosphate - آدنوزین cyclic 3 '، 5'-monophosphateLeft ventricular - بطن چپregulatory light chain - زنجیره سبک قانونیmyosin light chain kinase - زنجیره کیناز سبک مایوسینleucine zipper - زیپ لوسینsmooth muscle - عضله صاف Myosin light chain phosphatase - فسفاتاز زنجیره سبک میوزینPhosphodiesterase - فسفو دی استرازcyclic guanosine monophosphate - مونوفسفات گوانوزین چرخه ایHeart failure with preserved ejection fraction - نارسایی قلب با کسر خروجی حفظ شدهheart failure with reduced ejection fraction - نارسایی قلبی با کاهش کسر تخلیهknockout - ناکاوتNitric oxide - نیتریک اکسیدprotein kinase A - پروتئین کیناز Aprotein kinase G - پروتئین کیناز Gejection fraction - کسری خروجی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Patients with heart failure are commonly divided into those with reduced ejection fraction (EF<40%) and those with preserved ejection fraction (HFpEF; EF>50%). For heart failure with reduced EF, a number of therapies have been found to improve patient morbidity and mortality, and treatment is guideline based. However for patients with HFpEF, no treatment has been found to have clinical benefit. To objectively assess treatments for HFpEF, a comprehensive PubMed literature search was performed using the terms HFpEF, heart failure, smooth muscle, myosin, myosin phosphatase, and PKG (up to December 31, 2017), with an unbiased focus on pathophysiology, cell signaling, and therapy. This review provides evidence that could explain the lack of clinical benefit in treating patients with HFpEF with sildenafil and long-acting nitrates. Furthermore, the review highlights the vascular abnormalities present in patients with HFpEF, and these abnormalities of the vasculature could potentially contribute to the pathophysiology of HFpEF. Thus, focusing on HFpEF as a vascular disease could result in the development of novel and effective treatment paradigms.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mayo Clinic Proceedings - Volume 93, Issue 9, September 2018, Pages 1305-1314
Journal: Mayo Clinic Proceedings - Volume 93, Issue 9, September 2018, Pages 1305-1314
نویسندگان
Melissa A. MD, Frank V. MD, PhD,