کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8978221 1106586 2005 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Kinetics and distribution of bovine γδ T-lymphocyte in the intestine: γδ T cells accumulate in the dome region of Peyer's patch during prenatal development
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
Kinetics and distribution of bovine γδ T-lymphocyte in the intestine: γδ T cells accumulate in the dome region of Peyer's patch during prenatal development
چکیده انگلیسی
The kinetics and distribution of γδ T cells in bovine intestine including jejunal and ileal Peyer's patch were examined. The number of γδ T cells increased significantly in the dome region during prenatal development, but decreased notably after birth. The number of some γδ T cells, CD4+ cells, and CD8+ cells in the intestinal villi remained constant during prenatal development, but increased significantly after birth. The kinetics of the γδ T cells in the dome region during prenatal development were quite distinct from those of the γδ T cells, CD4+ cells, and CD8+ cells in the intestinal villi. In the fetal ileum at full-term gestation, the frequencies of expression of the T-cell receptor γ variable region (TCR Vγ) family were TCR Vγ1 (48%), Vγ2 (4%), and Vγ5 (48%). However, in 2-month-old calf ileum, TCR Vγ5 (90%) was dominant. We speculate that functional differences exist between γδ T cells in the dome region during prenatal development and in the intestinal villi after birth.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental & Comparative Immunology - Volume 29, Issue 6, 2005, Pages 555-564
نویسندگان
, , , , ,