“Determination of domperidone in tablet dosage form by anodic differential pulse voltammetry”

A differential pulse voltammetric method was described for the determination of domperidone. The method was based on the anodic oxidation of domperidone on a glassy carbon electrode at +0.64 V vs. SCE in Britton-Robinson buffer solution of pH 2.3. The reversibility of the oxidation was tested by cyclic voltammetry; the electrode process is irreversible and diffusion-adsorption controlled. Calibrations are linear over the range 1.0 × 10-6-2.0 × 10-5 M of domperidone with a detection limit of 4.0 × 10-7 M. The method was applied, without any interference from the excipients, to the determination of the drug in a tablet dosage form.