Determination of norfloxacin by highly accurate nephelometric titration

A highly accurate nephelometric titration for the determination of norfloxacin is presented. The titration operating conditions were studied and the solubility product constant of norfloxacin‐tetraphenylboron precipitation was determined. The result of the titration is comparable to those of control experiments. The proposed method has been found to be accurate, precise, specific, and linear. © 2004 Wiley‐Liss, Inc. and the American Pharmacists Association J Pharm Sci 94:540-546, 2005