کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8994338 | 1114390 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Determination of fluidized bed granulation end point using nearâinfrared spectroscopy and phenomenological analysis
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Simultaneous realâtime monitoring of particle size and moisture content by nearâinfrared spectroscopy through a window into the bed of a fluidized bed granulator is used to determine the granulation end point. The moisture content and particle size determined by the nearâinfrared monitor correlates well with offâline moisture content and particle size measurements. The measured particle size is modeled using a population balance approach, and the moisture content is shown to follow accepted models during drying. Given a known formulation, with predefined parameters for peak moisture content, final moisture content, and final granule size, the nearâinfrared monitoring system can be used to control a fluidized bed granulation by determining when binder addition should be stopped and when drying of the granules is complete. © 2005 WileyâLiss, Inc. and the American Pharmacists Association J Pharm Sci 94:604-612, 2005
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 94, Issue 3, March 2005, Pages 604-612
Journal: Journal of Pharmaceutical Sciences - Volume 94, Issue 3, March 2005, Pages 604-612
نویسندگان
W. Paul Findlay, Garnet R. Peck, Kenneth R. Morris,