کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8994360 | 1114394 | 2005 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dendrisomes: Vesicular Structures Derived from a Cationic Lipidic Dendron
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موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
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چکیده انگلیسی
The behavior of a novel synthetic lipidic cationic lysineâbased dendron (partial dendrimer) in aqueous media and its ability, with and without cholesterol, to selfâassemble into higher order structures was studied to gain an understanding of these structures as potential drug carriers. The dendron was prepared by solidâphase peptide synthesis. A reverseâphase evaporation (REV) technique was used to prepare cationic vesicular aggregates of the dendron with different molar ratios of cholesterol. The size and zeta potential of these supramolecular aggregates or “dendrisomes” was determined by photon correlation spectroscopy (PCS). Dendrisome morphology and thermotropic properties were studied by transmission electron microscopy (TEM) and differential scanning calorimetry (DSC). Radiolabeled penicillin G was used as a model of a negatively charged waterâsoluble compound to investigate the encapsulation efficiency of the dendrisomes. In vitro release of the drug was determined using as a comparator a REV liposome formulation. Dendrisomes of all compositions have higher encapsulation efficiencies and slower release rates compared to the comparator. Cholesterol was found both to increase the size of the aggregates from around 310 to 560 nm and to increase shape irregularities, but did not change the positive zeta potential, in the order of +50 mV, of the dendrisomes. Cholesterol decreases penicillin G entrapment efficiency but increases solute leakage at 25°C.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 94, Issue 1, January 2005, Pages 102-113
Journal: Journal of Pharmaceutical Sciences - Volume 94, Issue 1, January 2005, Pages 102-113
نویسندگان
Khuloud T. AlâJamal, Thiagarajan Sakthivel, Alexander T. Florence,