کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8998251 | 1115614 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Ascorbic acid inhibits ROS production, NF-κB activation and prevents ethanol-induced growth retardation and microencephaly
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کلمات کلیدی
NF-κBFASNCAMROS - ROSAscorbic acid - آسکوربیک اسیدEthanol - اتانولFetal development - توسعه جنینFetal alcohol syndrome - سندرم جنینی الکلNuclear factor-kappa B - فاکتور هسته ای-کاپا Bneural cell adhesion molecule - مولکول چسبندگی سلولی عصبیXenopus laevis - نام علمی قورباغه پنجهدار آفریقاییReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Ascorbic acid inhibits ROS production, NF-κB activation and prevents ethanol-induced growth retardation and microencephaly Ascorbic acid inhibits ROS production, NF-κB activation and prevents ethanol-induced growth retardation and microencephaly](/preview/png/8998251.png)
چکیده انگلیسی
In this study, we established an embryo model to study the effects of ethanol on fetal development. When embryos of Xenopus laevis (the African clawed frog) were exposed to ethanol, the resultant tadpoles had significantly reduced brain sizes (microencephaly) and retarded growth rates. These effects, similar to those observed in human fetal alcohol syndrome (FAS), were dose- and time-dependent. We further showed that the antioxidant ascorbic acid (vitamin C) could inhibit the ethanol-induced reactive oxygen species (ROS) production and NF-κB activation and protect the ethanol-treated embryos against microencephaly and growth retardation. These results suggest the involvement of NF-κB and oxidative stress in ethanol-mediated developmental defects, and the potential use of ascorbic acid as a new and effective protective agent for FAS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropharmacology - Volume 48, Issue 3, March 2005, Pages 426-434
Journal: Neuropharmacology - Volume 48, Issue 3, March 2005, Pages 426-434
نویسندگان
Ying Peng, K.H.H. Kwok, Pai-Hao Yang, Samuel S.M. Ng, Jie Liu, O.G. Wong, Ming-Liang He, Hsiang-Fu Kung, Marie C.M. Lin,