کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9004438 | 1119639 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Polysulfated sialic acid derivatives as anti-human immunodeficiency virus
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
تومور شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
We report the synthesis of a novel alkyl polysulfated sialic acid derivative denoted as NMSO3. NMSO3 exhibited potent inhibition against both laboratory and clinical human immunodeficiency virus type 1 (HIV-1). The anti-viral activity of this compound (1Â uM) was compared to dextran sulfate (3Â uM), and was found to be more potent against HIV-1IIIb than AZT (10Â uM). The anti-coagulation time was more than 15-fold shorter than that of dextran sulfate. An in vivo anti-viral study of NMSO3 in NOD-SCID-PBL mice HIV model showed complete protection of the animals from virus challenge at the concentration of 10Â mg/kg. This suggests that NMSO3 can be effective in the treatment of HIV-infected individuals.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomedicine & Pharmacotherapy - Volume 59, Issue 8, September 2005, Pages 423-429
Journal: Biomedicine & Pharmacotherapy - Volume 59, Issue 8, September 2005, Pages 423-429
نویسندگان
Masaki Terada, Shuji Fujita, Isao Suda, Robert Mastico,