کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9007880 | 1122720 | 2005 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Opposing effect of IFNγ and IFNα on expression of NKG2 receptors: Negative regulation of IFNγ on NK cells
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کلمات کلیدی
MHC class I-related chainMFIULBPMICKirnatural killer - (سلول های) کشنده طبیعیHuman leukocyte antigen - آنتی ژن لوسکسی انسانHLA - آنتیژن گلبول سفید انسانیTumor immunity - ایمنی تومورinterferon - اینترفرونIFN - اینترفرون هاinterferon-γ - اینترفرون-γNK cells - سلولهای NKmajor histocompatibility complex - مجموعه سازگاری بافتی اصلیMHC - مجموعه سازگاری بافتی اصلیNegative regulation - مقررات منفیmean fluorescence intensity - میانگین شدت فلورسانسkiller cell immunoglobulin-like receptor - گیرنده ایمونوگلوبولین مشابه سلول قاتل
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The effector functions of natural killer (NK) cells are regulated by integrated signals across an array of stimulatory and inhibitory receptors interacting with target cell surface ligands. The regulatory effect of interferon-α (IFNα) and interferon-γ (IFNγ) on expression of the family of NKG2 receptors, stimulatory NKG2D receptor and inhibitory NKG2A receptor, and cytolysis of the target tumor cells (MICA+ and HLA-E+) were studied. Results show that IFNγ and IFNα influence NK cell function differently. Interferon-α stimulates expression of stimulatory NKG2D receptors and inhibits the expression of inhibitory NKG2A receptors on NK cells. Contrary to the stimulatory effect of IFNα, IFNγ inhibits cytolysis by NK cells of tumor cells expressing MICA or HLA-E cell surface proteins. Blocking NKG2D or NKG2A receptor activity with monoclonal antibodies partly attenuates the inhibitory effect of IFNγ while promoting the effects of IFNα on NK cytolysis. These results show for the first time that IFNγ negatively regulates NK cells through NKG2 receptors, and that the balance between stimulatory and inhibitory signals through the NKG2 family of receptors may be controlled by two opposing interferons. Modulating the balance between stimulatory and inhibitory signals through cell surface receptors on NK cells may open a new approach to NK cell-based biotherapy for cancer and infectious diseases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Immunopharmacology - Volume 5, Issue 6, June 2005, Pages 1057-1067
Journal: International Immunopharmacology - Volume 5, Issue 6, June 2005, Pages 1057-1067
نویسندگان
Cai Zhang, Jian Zhang, Rui Sun, Jinbo Feng, Haiming Wei, Zhigang Tian,