کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9009728 | 1124079 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Biologically active bisbenzylisoquinoline alkaloids from the root bark of Epinetrum villosum
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Methanol and water extracts of the root of Epinetrum villosum (Exell) Troupin (Menispermaceae) were found to exhibit antimicrobial and antiplasmodial activities. Investigation of the active methanol fraction led to the isolation of four bisbenzylisoquinoline alkaloids, i.e., cycleanine, cycleanine N-oxide, isochondodendrine and cocsoline. Structures were established by spectroscopic methods. Cocsoline displayed antibacterial and antifungal activities (MIC values of 1000-15.62 and 31.25 μg/ml, respectively). Isochondodendrine was found to have the most potent antiplasmodial activity (IC50 = 0.10 μg/ml), whereas the IC50 on HCT-116 human colon carcinoma cells was 17.5 μg/ml (selectivity index 175). Cycleanine acted against HIV-2 (EC50 = 1.83 μg/ml) but was at least 10-fold less active against HIV-1. Cycleanine N-oxide showed no activity towards all tested microorganisms.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 102, Issue 1, 31 October 2005, Pages 89-94
Journal: Journal of Ethnopharmacology - Volume 102, Issue 1, 31 October 2005, Pages 89-94
نویسندگان
A. Longanga Otshudi, S. Apers, L. Pieters, M. Claeys, C. Pannecouque, E. De Clercq, A. Van Zeebroeck, S. Lauwers, M. Frédérich, A. Foriers,