کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9009940 1560417 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of Saponins of Albizia lebbeck (L.) Benth bark on the reproductive system of male albino rats
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Effect of Saponins of Albizia lebbeck (L.) Benth bark on the reproductive system of male albino rats
چکیده انگلیسی
Oral administration of saponins isolated from Albizia lebbeck bark at the dose level of 50 mg/kg/b.w. per day for 60 days to male rats brought about a significant decrease in the weights of testes, epididymides, seminal vesicle and ventral prostate. The production of round spermatid was reduced by 73.04% in Albizia lebbeck treated rats. The population of preleptotene spermatocytes and spermatogonia were reduced by 65.07% and 47.48% and secondary spermatocytes by 73.41%, respectively. Cross sectional surface area of Sertoli cells as well as the cell counts were found to be depleted significantly. Leydig cell nuclear area and number of mature Leydig cells were decreased by 57.47% and 54.42%, respectively. Sperm motility as well as sperm density were reduced significantly. Albizia lebbeck reduced the fertility of male rats by 100%. There were no significant changes in RBC and WBC count, haemoglobin, haematocrit and glucose in the blood and cholesterol, protein, triglyceride and phospholipid in the serum. The protein, glycogen and cholesterol contents of the testes, fructose in the seminal vesicle and protein in epididymides were significantly decreased. Histoarchitecture of the testes showed vacuolization at primary spermatocytes stage. Highly reduced seminiferous tubular diameter and increased intertubular space were also observed when compared to controls.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 96, Issues 1–2, 4 January 2005, Pages 31-36
نویسندگان
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