Vasorelaxant effects of the chloroformic crude extract of Bupleurum fruticosum L. (Umbelliferae) roots on rat thoracic aorta

Finally, the chloroformic extract of Bupleurum fruticosum produced a reduction of the contraction obtained by caffeine, an opener of ryanodine-sensitive receptors, suggesting that the plant could elicit the vasorelaxing response by the blockade of ryanodine-sensitive Ca2+ channels of the sarcoplasmic reticulum.