کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9010234 | 1124104 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of the extracts and fractions of Baccharis trimera and Syzygium cumini on glycaemia of diabetic and non-diabetic mice
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
In the present study, we investigated the effects of extracts and fractions of Baccharis trimera and Syzygium cumini on glycaemia of diabetic and non-diabetic mice. Crude ethanolic extracts and aqueous and butanolic fractions of the aerial parts of Baccharis trimera and leaves of Syzygium cumini were evaluated. None of the extracts or fractions (200 or 2000Â mg/kg, per os) induced any effect after acute administration. Seven-day treatment with crude ethanolic and aqueous and butanolic fractions (200-2000Â mg/kg, twice daily, per os) of Syzygium cumini reduced glycaemia of non-diabetic mice. However, this effect was associated with a reduction of food intake and body weight, indicating that this may not be a genuine hypoglycaemic effect. In diabetic mice, only the aqueous fraction of Baccharis trimera (2000Â mg/kg, twice daily, per os) reduced the glycaemia after a 7-day treatment. This effect was not associated with a body weight reduction. The results suggest that Baccharis trimera presents a potential antidiabetic activity and indicate that food intake and body weight must be determined when evaluating metabolic parameters after prolonged administration of plant extracts.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 102, Issue 3, 1 December 2005, Pages 465-469
Journal: Journal of Ethnopharmacology - Volume 102, Issue 3, 1 December 2005, Pages 465-469
نویسندگان
Antônio Carlos P. Oliveira, Denise C. Endringer, Luiz Alberto S. Amorim, Maria das Graças L. Brandão, Márcio M. Coelho,