کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9010551 | 1560415 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Inhibition of rat vascular smooth muscle cell proliferation by extract of Ligusticum chuanxiong and Angelica sinensis
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Ligusticum chuanxiong (LC) and Angelica sinensis (AS) have been widely used as traditional Chinese medicine to treat some pathological settings such as atherosclerosis and hypertension. The aim of this paper is to determine the effects of the extract of LC and AS (ELCAS) on serum-induced vascular smooth muscle cell (VSMC) proliferation, cell cycle and nitric oxide production. The results show that ELCAS significantly inhibited proliferation and protein synthesis of VSMC in a dose and time dependent manner. The cell population assessed by flow cytometry in the G0/G1 phase increased 74% versus 79.8%, concomitant with a decrease in the S phase, 7.4% versus 4.2%, for control versus ELCAS (300 μg/ml). On the other hand, ELCAS significantly increased nitric oxide production of VSMC. The data suggest that ELCAS markedly inhibited VSMC proliferation by arresting G1 to S progression, which may be associated with nitric oxide production.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 100, Issues 1â2, 22 August 2005, Pages 140-144
Journal: Journal of Ethnopharmacology - Volume 100, Issues 1â2, 22 August 2005, Pages 140-144
نویسندگان
Yong-Zhong Hou, Guang-Rong Zhao, Ying-Jin Yuan, Guo-Guang Zhu, Raimo Hiltunen,