کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9015219 1127142 2005 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Chemopotentiation by PARP inhibitors in cancer therapy
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Chemopotentiation by PARP inhibitors in cancer therapy
چکیده انگلیسی
PARP inhibitors have been shown to restore sensitivity of resistant tumors to methylating agents or topoisomerase I inhibitors, drugs presently used for the treatment of primary and secondary brain tumors or malignancies refractory to standard chemotherapy. Interestingly, PARP inhibitors may also provide protection from the untoward effects exerted by certain anticancer drugs, which cause oxidative stress and consequent PARP overactivation. The aim of this article is to provide a brief overview of the recent literature on preclinical studies with the specific and potent inhibitors newly synthesized.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacological Research - Volume 52, Issue 1, July 2005, Pages 25-33
نویسندگان
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