کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9015224 | 1127142 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Poly(ADP-ribosyl)ation in asthma and other lung diseases
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کلمات کلیدی
Asbestosis - آزبستوزAsthma - آسمAllergy - آلِرژیinflammation - التهاب( توروم) Oxidative stress - تنش اکسیداتیوAcute respiratory distress syndrome - سندرم دیسترس تنفسی حادCytokines - سیتوکین هاSilicosis - سیلیکوزیسPeroxynitrite - پروکسی نیتریتPoly(ADP-ribose) polymerase - پلیمر (ADP-ribose) پلیمرازChemokines - کرموین ها
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
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چکیده انگلیسی
Inhibition of poly(ADP-ribosyl)ation in oxidative stress-related pathologies has recently emerged as a very effective anti-inflammatory intervention in animal models of arthritis, colitis, diabetes and shock. Recent data from three laboratories also support the role of poly(ADP-ribose) polymerase-1 (PARP-1) activation in asthma. Similarly to other inflammatory conditions, the protective effects of PARP inhibition and the PARP-1 knock out phenotype in asthma models have been attributed to inhibition of inflammatory signal transduction (mainly via NF-κB) and of oxidative stress-induced cell dysfunction and tissue injury. Here I discuss the complex role of poly(ADP-ribosyl)ation in the regulation of inflammatory cell migration, chemokine and cytokine production and expression of other inflammatory mediators (inducible nitric oxide synthase, matrix metalloproteinases) in asthma. The role of PARP-1 in other oxidative stress-related lung diseases such as asbestosis, silicosis, acute respiratory distress syndrome and ischemia-reperfusion injury is also reviewed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacological Research - Volume 52, Issue 1, July 2005, Pages 83-92
Journal: Pharmacological Research - Volume 52, Issue 1, July 2005, Pages 83-92
نویسندگان
László Virág,