کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9017383 | 1128366 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Time to change diagnostic criteria of ARDS: toward the disease entity-based subgrouping
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
پزشکی ریوی و تنفسی
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چکیده انگلیسی
Because of high mortality and morbidity, acute respiratory distress syndrome (ARDS) continues to be one of the clinical challenges for intensivists. The diagnostic criteria for ARDS published by the American-European consensus conference were over simplified and made it possible to conduct large-scale randomized controlled trials (RCTs). Thus, many RCTs have been conducted in attempts to evaluate new treatment modalities, but many have reported negative results, in part because this definition was too broad to be used as diagnostic criteria. Pulmonary ARDS and extrapulmonary ARDS differ in terms of their morbidity and mortality with the presence of organ failure being an important risk factor for mortality in ARDS patients. The Classification of ARDS into several subgroups, which take the underlying disease into account, might limit the number of the patients enrolled in an RCT. Where as this subgroup classification would enable selection of a homogeneous population of ARDS patients and may be a key to conducting more focused RCTs and, therefore, having more reliable results.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pulmonary Pharmacology & Therapeutics - Volume 18, Issue 2, April 2005, Pages 115-119
Journal: Pulmonary Pharmacology & Therapeutics - Volume 18, Issue 2, April 2005, Pages 115-119
نویسندگان
Shinhiro Takeda, Akitoshi Ishizaka, Yuji Fujino, Toshio Fukuoka, Osamu Nagano, Yoshitsugu Yamada, Jun Takezawa, Multicenter Clinical Trial Committee Multicenter Clinical Trial Committee,