کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9017384 | 1128366 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Inhibition of endotoxin- and antigen-induced airway inflammation by fudosteine, a mucoactive agent
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موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
پزشکی ریوی و تنفسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Inhibition of endotoxin- and antigen-induced airway inflammation by fudosteine, a mucoactive agent Inhibition of endotoxin- and antigen-induced airway inflammation by fudosteine, a mucoactive agent](/preview/png/9017384.png)
چکیده انگلیسی
We evaluated the effect of a mucoactive agent (â)-(R)-2-amino-3-(3-hydroxypropylthio) propionic acid (fudosteine), on airway inflammation using endotoxin- and antigen-induced models. Time courses of growth related oncogene/cytokine-induced neutrophil chemoattractant-1 (GRO/CINC-1) production, neutrophil migration and goblet cell hyperplasia were examined in endotoxin-induced rat airway inflammation. GRO/CINC-1 in bronchoalveolar lavage fluid (BALF) increased in response to intratracheal instillation of endotoxin and peaked within 4Â h. Neutrophils in BALF and goblet cells on trachea peaked 24 and 96Â h after endotoxin instillation, respectively. Fudosteine significantly inhibited increases in GRO/CINC-1 at 10-100Â mg/kg, and neutrophils and goblet cells at 30 and 100Â mg/kg. These results suggest that inflammatory events including neutrophil chemoattractant production and neutrophil migration play important roles for goblet cell hyperplasia in endotoxin-induced airway inflammation, and fudosteine inhibits goblet cell hyperplasia by inhibiting GRO/CINC-1 production and/or neutrophil migration. Furthermore, fudosteine (100Â mg/kg) inhibited ovalbumin-induced eosinophil infiltration into BALF, suggesting it attenuates asthmatic inflammation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pulmonary Pharmacology & Therapeutics - Volume 18, Issue 2, April 2005, Pages 121-127
Journal: Pulmonary Pharmacology & Therapeutics - Volume 18, Issue 2, April 2005, Pages 121-127
نویسندگان
H. Komatsu, S. Yamaguchi, N. Komorita, K. Goto, S. Takagi, H. Ochi, T. Okumoto,