کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9017772 1128665 2005 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Comprehensive non-clinical respiratory evaluation of promising new drugs
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Comprehensive non-clinical respiratory evaluation of promising new drugs
چکیده انگلیسی
The need to evaluate the potential for new drugs to produce adverse effects on respiratory function in non-clinical safety assessment is based on the known effects of drugs from a variety of pharmacological/therapeutic classes on the respiratory system, the life-threatening consequences of respiratory dysfunction, and compliance with world-wide regulatory safety guidelines. The objective of this article is to provide a brief overview of the functional disorders of the respiratory system and to present the strategy and techniques considered to be most appropriate for detecting and characterizing drug-induced respiratory disorders in non-clinical safety studies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology and Applied Pharmacology - Volume 207, Issue 2, Supplement, 1 September 2005, Pages 414-424
نویسندگان
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