کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9017892 | 1128675 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Anti-allergic effects of Lycopus lucidus on mast cell-mediated allergy model
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
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![عکس صفحه اول مقاله: Anti-allergic effects of Lycopus lucidus on mast cell-mediated allergy model Anti-allergic effects of Lycopus lucidus on mast cell-mediated allergy model](/preview/png/9017892.png)
چکیده انگلیسی
The current study characterizes the mechanism by which the aqueous extract of Lycopus lucidus Turcz. (Labiatae) (LAE) decreases mast cell-mediated immediate-type allergic reaction. The immediate-type allergic reaction is involved in many allergic diseases such as asthma and allergic rhinitis. LAE has been used as a traditional medicine in Korea and is known to have an anti-inflammatory effect. However, its specific mechanism of action is still unknown. LAE was anally administered to mice for high and fast absorption. LAE inhibited compound 48/80-induced systemic reactions in mice. LAE decreased the local allergic reaction, passive cutaneous anaphylaxis, activated by anti-dinitrophenyl (DNP) IgE antibody. LAE dose-dependently reduced histamine release from rat peritoneal mast cells activated by compound 48/80 or anti-DNP IgE. Furthermore, LAE decreased the secretion of TNF-α and IL-6 in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated human mast cells. The inhibitory effect of LAE on the pro-inflammatory cytokine was p38 mitogen-activated protein kinase (MAPK) and nuclear factor-κB (NF-κB) dependent. LAE attenuated PMA plus A23187-induced degradation of IκBα and nuclear translocation of NF-κB, and specifically blocked activation of p38 MAPK, but not that of c-jun N-terminal kinase and extracellular signal-regulated kinase. Our findings provide evidence that LAE inhibits mast cell-derived immediate-type allergic reactions and involvement of pro-inflammatory cytokines, p38 MAPK, and NF-κB in these effects.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology and Applied Pharmacology - Volume 209, Issue 3, 15 December 2005, Pages 255-262
Journal: Toxicology and Applied Pharmacology - Volume 209, Issue 3, 15 December 2005, Pages 255-262
نویسندگان
Tae-Yong Shin, Sang-Hyun Kim, Kyoungho Suk, Jeoung-Hee Ha, InKyeom Kim, Maan-Gee Lee, Chang-Duk Jun, Sang-Yong Kim, Jong-Pil Lim, Jae-Soon Eun, Hye-Young Shin, Hyung-Min Kim,