کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9020823 | 1129726 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
An ethyl acetate fraction obtained from a Southern Brazilian red wine relaxes rat mesenteric arterial bed through hyperpolarization and NO-cGMP pathway
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موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
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چکیده انگلیسی
Our results showed that after the tonus of MAB was increased with phenylephrine (PE), increasing concentrations of CE induced a concentration-dependent relaxation; moreover, EAF was more potent in relaxing the MAB when compared with CE. In vessels depolarized with KCl (80 mM) or treated with the Na+/K+-ATPase pump inhibitor, ouabain (OUA; 100 μM), or with the K+ channel blockers: barium (BaCl2, 100 μM) and tetraethylammonium (TEA; 500 μM ), the effect of EAF was significantly reduced. However, this effect was not altered by the ATP-dependent K+ (KATP) channel blocker, glibenclamide (GLI; 100 μM) as well as Charybdotoxin (ChTx 10 nM), a nonselective inhibitor of KCa channels of large and intermediate conductance plus Apamin (Apamin 100 nM), a specific inhibitor of KCa channels of small conductance. The residual vasodilator effect of EAF observed in vessels pretreated with L-NOARG (100 μM), 1H-[1,2,4,] oxadiazolo[4,3-alfa]quinoxalin, ODQ (10 μM) or KCl (80 mM), given separately, was reduced by the administration of KCl (40 mM) plus L-NOARG (100 μM). The present study demonstrates that the vasodilator effect of EAF is partially dependent upon membrane hyperpolarization in combination with nitric oxide (NO) release.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vascular Pharmacology - Volume 43, Issue 1, June 2005, Pages 62-68
Journal: Vascular Pharmacology - Volume 43, Issue 1, June 2005, Pages 62-68
نویسندگان
Elke Zuleika Schuldt, Ãngela Cristina Bet, Mariana Appel Hort, Carla Ianssen, Marcelo Maraschin, Karina Ckless, Rosa Maria Ribeiro-do-Valle,