کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9030066 | 1130717 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Developmental neurotoxicity of chlorpyrifos: targeting glial cells
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کلمات کلیدی
GFAPMBPNF200CPFROS - ROSACh - آهAChE - آهیAcetylcholine - استیل کولینAcetylcholinesterase - استیل کولین استرازBrain development - رشد مغز gestational day - روز بارداریpostnatal day - روز پس از زایمانneurofilament - نوروفیلامنتGlial fibrillary acidic protein - پروتئین اسیدی فیبریلاسیون گلایالMyelin basic protein - پروتئین پایه میلینChlorpyrifos - کلرپیریفوسC6 glioma - گلیوم C6Reactive oxygen species - گونههای فعال اکسیژنGlia - یاختههای گلیال
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Developmental neurotoxicity of chlorpyrifos: targeting glial cells Developmental neurotoxicity of chlorpyrifos: targeting glial cells](/preview/png/9030066.png)
چکیده انگلیسی
The pesticide chlorpyrifos (CPF) causes neurobehavioral damage, even at doses that do not elicit acute cholinergic toxicity. CPF disrupts the developing brain during glial proliferation and differentiation. Since glial cells play critical roles in brain development and function, we hypothesized that CPF neurotoxicity involves alteration of glial cell development. CPF effects in C6 glioma cells mirrored effects in the intact brain: inhibited DNA synthesis; interfered with adenylyl cyclase (AC) signaling; obstructed DNA binding to transcription factors involved in cell differentiation; and enhanced reactive oxygen species (ROS) formation. CPF was administered to prenatal and neonatal rats and examined for markers of astrocytes, oligodendrocytes, and neurons. Widespread effects were elicited by exposure during the peak period of gliogenesis. Males were preferentially targeted during postnatal exposures while females experienced delayed effects following gestational exposure, commensurate with behavioral outcomes. Alterations in glial cell development contribute to CPF neurotoxicity, extending vulnerability to myelination, synaptic plasticity, and architectural modeling, which continue into adolescence.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Toxicology and Pharmacology - Volume 19, Issue 3, May 2005, Pages 455-461
Journal: Environmental Toxicology and Pharmacology - Volume 19, Issue 3, May 2005, Pages 455-461
نویسندگان
Stephanie J. Garcia, Frederic J. Seidler, Theodore A. Slotkin,