کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9030641 | 1130932 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of betaine supplementation on changes in hepatic metabolism of sulfur-containing amino acids and experimental cholestasis induced by α-naphthylisothiocyanate
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کلمات کلیدی
α-naphthylisothiocyanateBHMT, betaine homocysteine methyltransferaseANIT, α-naphthylisothiocyanateALP, alkaline phosphatase - ALP، قلیایی فسفاتازMAT, methionine adenosyltransferase - MAT، متیونین آدنوزیلت ترانسفرازSAH, S-adenosylhomocysteine - SAH، S-adenosylhomocysteineSAM, S-adenosylmethionine - SAM، S-آدنوزیل متیونینAST, aspartate aminotransferase - آزمایش آسپارتات آمینوترانسفرازALT, alanine aminotransferase - آلانین آمینوترانسفرازS-adenosylmethionine - اس-ادنوزیل متیونینSulfur amino acid - اسید آمینه سولفوریکBetaine - بتائینTranssulfuration - ترانسفوروسیونcholestasis - کلستاز GSH, glutathione - گلوتاتیون
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Alterations in the hepatic metabolism of sulfur amino acids in experimental cholestasis induced by α-naphthylisothiocyanate (ANIT) (100 mg/kg, po) were monitored in male mice for 1 week. We also examined the effects of betaine supplementation (1% in drinking water) for 2 weeks on the hepatotoxicity and changes in the sulfur amino acid metabolism induced by ANIT treatment. Acute ANIT challenge elevated the serum alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST) activities, and total bilirubin contents from 5 h after the treatment, reaching a peak at t = 48-72 h. Hepatic S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) levels were decreased significantly in a manner almost inversely proportional to the changes in serum parameters measured to determine the ANIT-induced toxicity. Hepatic glutathione and cysteine levels were elevated at t = 120 h after the treatment. Betaine supplementation blocked or significantly attenuated induction of the hepatotoxicity by ANIT. The decrease in SAM and SAH levels was also inhibited by betaine intake. The results indicate that betaine supplementation may antagonize the induction of experimental cholestasis and changes in the metabolism of sulfur amino acids associated with ANIT treatment. The underlying mechanism and pharmacological significance of its action are discussed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 43, Issue 5, May 2005, Pages 663-670
Journal: Food and Chemical Toxicology - Volume 43, Issue 5, May 2005, Pages 663-670
نویسندگان
Young C. Kim, Young S. Jung, Sang K. Kim,