Secondary preeclampsia in rats with nephrotic syndrome - experimental model

The purpose of the study was to investigate the influence that pregnancy has on the progression of primary nephrotic syndrome (NS). We investigated in pregnant rats the clinical characteristics of NS, including urinary protein concentration, serum albumin, cholesterol, triglycerides, urea, creatinine and electrolytes (potassium, sodium, calcium). Proteinuria and edema increasing during pregnancy, hyponatremia, and also exudates to body cavities were signs of secondary preeclampsia. Hypertension appeared in the second half of pregnancy (from the 10th day) and increased during the perinatal period. All signs of preeclampsia disappeared after puerperium, leaving only the signs of NS existing before pregnancy. Primary, idiopathic gestosis occurs only in humans; therefore, research on that type of gestosis should be confirmed clinically.