کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9036803 1133373 2005 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of in utero and lactational exposure to tamoxifen in SD rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Effects of in utero and lactational exposure to tamoxifen in SD rats
چکیده انگلیسی
Pregnant CD (SD) IGS rats were given tamoxifen (TMX) orally at doses of 0.12, 0.6, or 3 μg/kg/day from gestational day 6 to postnatal day 21, and the effects of TMX exposure on all offspring were examined 10 weeks after birth; the reproductive performance of the offspring was also evaluated. Although the body weights of the dams treated with TMX remained normal from gestational day 6 until the day of autopsy (postnatal day 21), three dams in the 3 μg/kg/day group died during the pregnancy or partum periods. These deaths were regarded as the toxicological effects of TMX. No changes were detected in the reproductive parameters of all the TMX groups except for a decrease in the number of newborns/live newborns in the 3 μg/kg/day group. No abnormal clinical signs, body weight change, ano-genital distance, vaginal opening, or organ weight changes were detected in any of TMX groups, but the day of preputial separation was prolonged in the male offspring of all TMX groups and cleft phallus was detected in the female offspring of the 0.6 and 3 μg/kg/day groups. No abnormalities were detected in the reproductive performance of the male and female offspring.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology Letters - Volume 156, Issue 2, 10 April 2005, Pages 289-296
نویسندگان
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