کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9037219 | 1133416 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cholesterol as target of Fe-NTA-induced lipid peroxidation in rat tissues
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Cholesterol as target of Fe-NTA-induced lipid peroxidation in rat tissues Cholesterol as target of Fe-NTA-induced lipid peroxidation in rat tissues](/preview/png/9037219.png)
چکیده انگلیسی
Intraperitoneal injection of the iron-chelate, ferric-nitrilotriacetate (Fe-NTA), induces renal proximal tubular damage associated with oxidative damage in vivo. A sub-lethal dose of Fe-NTA (15Â mg Fe/kg body weight) was administered IP to rats; animals were sacrificed and liver, kidney and plasma were collected 1-4Â h after injection. In response to the Fe-NTA administration, there were significant time-dependent reductions of the levels of total lipids, cholesterol and total unsaturated fatty acids, and a rise in the concentrations of conjugated dienes, 7-ketocholesterol and fatty acids hydroperoxides, showing a pattern inversely correlated in plasma, kidney and liver. Cholesterol level decreased significantly from 1Â h after injection in the kidney and 3-4Â h in the plasma and liver of treated rats. This is the first report on cholesterol reduction and accumulated 7-ketocholesterol in the tissues of rats treated with Fe-NTA as a consequence of lipid peroxidation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology Letters - Volume 157, Issue 1, 16 May 2005, Pages 1-8
Journal: Toxicology Letters - Volume 157, Issue 1, 16 May 2005, Pages 1-8
نویسندگان
Antonella Rosa, Monica Deiana, Giulia Corona, Angela Atzeri, Alessandra Incani, M. Assunta Dessì,